The hexanoate ester is quite similar to

the well known enanthate ester, but is shorter by one carbon.

Store this medicine at room temperature 77 degrees F (25 degrees C) in a tightly-closed container, away from heat, moisture, and light. Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted.

Tadalafil is currently undergoing clinical trials for the treatment of pulmonary hypertension. The clinical trials are based on tadalafil's inhibitiong of PDE5. It is hoped that by inhibiting this enzyme, tadalafil will prove effective in opening up blood vessels in the lungs, lowering pulmonary arterial resistance and pressure,

and thus reducing the workload of the right ventricle of the heart.

Tadalafil is currently undergoing clinical trials for the treatment of pulmonary hypertension. The clinical trials are based on tadalafil's inhibitiong of PDE5. It is hoped that by inhibiting this enzyme, tadalafil will prove effective in opening up blood vessels in the lungs, lowering pulmonary arterial resistance and pressure, and thus reducing the workload of the right ventricle of the heart.

Male athletes also find Clomid interesting. In men using Clomid, the elevation in both follicle stimulating hormone and (primarily) luteinizing

hormone will cause natural testosterone production to increase. This effect is especially beneficial to the athlete at the conclusion of a steroid cycle when endogenous testosterone levels are depressed. If endogenous testosterone levels are not brought beck to normal, a dramatic loss in size and strength is likely to occur once the anabolics have been removed. Clomid can play a crucial role in preventing this crash in athletic performance.

It is important to note however, that this drug does not directly convert to estrogen in the body. Oxymetholone is a derivative of dihydrotestosterone, which gives it

a structure that cannot be aromatized. As such, many have speculated as to what makes this hormone so troublesome in terms of estrogenic side effects. Some have suggested that it has progestational activity, similar to nandrolone, and is not actually estrogenic at all. Since the obvious side effects of both estrogens and progestins are very similar, this explanation might be a plausible one. However we do find medical studies looking at this possibility. One such tested the progestational activity of various steroids including nandrolone, norethandrolone, methandrostenolone, testosterone and oxymetholone 3. It reported

no significant progestational effect inherent in oxymetholone or methandrostenolone, slight activity with testosterone and strong progestational effect inherent in nandrolone and norethandrolone. With such findings it starts to seem much more likely that oxymetholone can intrinsically activate the estrogen receptor itself, similar to but more profoundly than the estrogenic androgen methAndriol. In speaking with chemist Patrick Arnold about my thoughts on this, I was afforded very believable support for my suspected explanation. According to Pat: "I share your thoughts on this. Anadrol has an acidic hydrogen in the A-ring

at a vicinity that is approximate to where the acidic phenolic hydrogen of estradiol is. I suspect it is a potent estrogen agonist". Clearly if this is the case we can only combat the estrogenic side effects of oxymetholone with estrogen receptor antagonists such as Nolvadex or Clomid, and not with an aromatase inhibitor. The strong anti-aromatase compounds such as Cytadren and Arimidex would similarly prove to be totally useless with this steroid, as aromatase is uninvolved.

Day 3: 80 mcg

Stanabol is a relatively low androgenic steroid which does not seem to aromatize. It can be toxic to the liver

in excessive dosages. Very few user report water retention or any other side effects. It is a popular all purpose steroid, many stack with Primobolan or Parabolan for cutting, others stack it with testosterone for size and strength gains. Women often use Winstrol depot but occasionally it can cause virilization, even at low dosages. Users report that the muscle gains they make are solid, they are well retained after the drug use is discontinued. Athletes also find that the injectable version is far superior to the oral.

Open the sachet(s). Spread a thin layer of Androgel / Cernos Gel onto clean dry healthy

skin over the upper arms, shoulders or stomach. Allow the gel to dry for at least 3-5 minutes before dressing. Wash your hands thoroughly with soap and water after applying the gel. Cover the application area with clothing once the gel has dried. Do not shower for at least six (6) hours after applying Androgel / Cernos Gel.

Detection time: 17-18 months.

The side effects of Proviron in men are low at a dosage of 24 tab-lets/day so that Proviron, taken for example in combination with a steroid cycle, can be used comparatively without risk over several weeks. Since Proviron is well-tolerated by the

liver, liver dysfunc-tions do not occur in the given dosages. For athletes who are used to acting under the motto "more is better" the intake of Proviron could have a paradoxical effect. The most common side effect of Proviron is a distinct sexual overstimulation and in some cases continuous penis erection. Since this condition can be painful and lead to possible damages, a lower dosage or discontinu-ing the compound are the only sensible solutions. Female athletes should use Proviron with caution since possible androgenic side ef-fects cannot be excluded. Women who want to give Proviron a try should not take
more than one 25 mg tablet per day. Higher dosages and periods of intake of more than four weeks considerably increase the risk of virilization symptoms. Female athletes who have no dif-ficulties with Proviron obtain good results with 25 mg Proviron/ day and 20 mg Nolvadex/day and, in combination with a diet, re-port an accelerated fat breakdown and continuously harder muscles.

Testosterone Propionate 50mg made by Brovel is a common oil based injectable Testosterone. The added Propionate extends the activity of the Testosterone but it is still comparatively much faster acting than other Testosterone esters

such as Cypionate and Enanthate. While Cypionate and Enanthate are injected weekly, Propionate is most commonly injected at least every third day to keep blood levels steady. For strength and muscle mass gains, this drug is quite effective. With Test Propionate, Androgenic side effects are less pronounced than with the other Testosterones, probably due to the fact that blood levels do not build up as high. Users often report less gyno trouble, lower water retention and commonly claim to be harder on Propionate than with the others.

Its growth promoting effect also seems to strengthen connective tissues, cartilage

and tendons. This effect should reduce the susceptibility to injury (due to heavy weight training), and increase lifting ability (strength). HGH is also a safe drug for the "piss-test". Although its use is banned by athletic committees, there is no reliable detection method. This makes clear its attraction to (among others) professional bodybuilders, strength athletes and Olympic competitors, who are able to use this drug straight through a competition. There is talk however that a reliable test for the exogenous administration of growth hormone has been developed, and is close to being implemented.

Until this happens, growth hormone will remain a highly sought after drug for the tested athlete.

Day 5: 80 mcg (Note: Increase the dose only when the side effects are tolerable)

How to take Reductil

Muscle Soreness - This is yet another thing that may be minimized via cerebral function. Dan Duchaine has recommended using a weight such as to allow no fewer than 15 reps per set of any weight training workout; judging from anecdotal reports and personal experience, this seems to be good advice. Low levels of ATP are a cause of muscle soreness in and of itself; the additional factor of encumbered

recovery mechanisms make extreme soreness (and if not careful, catabolism) quite possible.

50mg tablets are yellow hexagon shaped tablets, with "50" imprinted on one side and a score on the reverse, sealed in bags of 100tabs.

• It improves on wrinkle disappearance (51%)

CIALIS is not for everyone. If you take nitrates, often used for chest pain (also known as angina), or alpha-blockers (other than Flomax 0.4 mg once daily), prescribed for prostate problems or high blood pressure, do not take CIALIS. Such combinations could cause a sudden, unsafe drop in blood pressure. Don't drink

alcohol in excess (to a level of intoxication) with CIALIS. This combination may increase your chances of getting dizzy or lowering your blood pressure. CIALIS does not protect a man or his partner from sexually transmitted diseases, including HIV.

Primobolan Depot

It is also important that endogenous testosterone production is likely to be suppressed after a cycle of this drug. When this occurs, one runs the risk of losing muscle mass once the steroid is discontinued. HCG and/or Clomid are in most cases considered to be a necessity, used effectively to restore natural testosterone production and avoid

a post-cycle "crash". The user should always expect to see some loss of body weight when the steroids is discontinued, as retained water (accounting for considerable weight) will be excreted once hormone levels regulate. This weight loss is to be ignored, and the athlete should be concerned only with preserving the quality muscle that lies underneath. With the proper administration of ancillary drugs, much of the new muscle mass can be retained for a long time after the steroid cycle has been stopped. Those who rely solely on a fancy tapering-off schedule to accomplish this are likely to be disappointed. Although

a common practice, this is really not an effective way to restore the hormonal balance.

Miller suggests that an athlete who is engaged in a prolonged strenuous event should consume between 30 and 60 grams of carbohydrate per hour during the event.

Human Chorionic Gonadotropin is an injectable drug available commercially in the United States as well as many other countries. Pregnyl, made by Organon, and Profasi, made by Serono. Among athletes, HCG is used to stimulate natural testosterone production during or after a steroid cycle which has caused natural levels to be reduced, often stacked with clomid for

even better results.

Viagra is a breakthrough treatment that improves a man's response to sexual stimulation. We provide a Impotence simple, secure and confidential way to be evaluated for Viagra®. We bring you the privacy Impotence of an online consultation and an easy, inexpensive Impotence means of obtaining Viagra®.

Tell your doctor if you are pregnant or if you intend to become pregnant. Tamoxifen should not be used to reduce the risk of breast cancer if you are pregnant of if you intend to become pregnant. Tamoxifen use in women has been shown to cause miscarriages, birth defects, death

of the fetus, and vaginal bleeding.

The only prohibitive thing about Teslac is cost. Currently, I don´t know of any online pharmacies who carry it,nor UG Labs& and it generally sells for anywhere between a dollar and $5 for a 250mg tab. If there´s anything preventing this stuff from becoming the "must have" drug for PCT overnight, it´s the cost.

Somatotropin HGH / 10vials / original box Description Somatotropin hgh by EuroHormones

Keep oxandrolone in a tightly closed container and out of reach of children. Store oxandrolone at room temperature and away from excess heat

and moisture (not in the bathroom).

For most patients, KAMAGRA should be taken once a day as needed. In patients taking certain protease inhibitors (such as for the treatment of HIV), it is recommended to not exceed a maximum single dose of 25 mg of KAMAGRA in a 48-hour period.

Reductil works like other appetite suppressants on the market by increasing the amount of serotonin and catecholamine in the brain. Serotonin and catecholamine are two important chemicals that control mood and appetite. When levels of serotonin and catecholamine are raised, your appetite decreases.

Usual side effects

associated with this drug are high blood pressure, flu symptoms, joint and bone pain, tremors/chills, injection site inflammation (resides after a few days 3-4), and headaches.

Testosterone enanthate is an ester of the naturally occurring androgen, testosterone. It is responsible for the normal development of the male sex characteristics. In the event of insufficient testosterone production an almost complete balance of the functional, anatomic, and psychic deficiency symptoms can be achieved by substituting testosterone. One of the many testosterone substances is the testosterone enanthate. In a man it is normally

used to treat hypogonadism resulting from androgen deficiency and anemia. Surprisingly, in medical schools testosterone enanthate is also used in women and children. Boys and male youth take it as growth therapy. In bodybuilding, however, it is THE "mass building steroid." No matter what you think of Dianabol, Parabolan, Anadrol 50, Finaject, and others, when it comes to strength, muscle mass, and rapid weight gains, testosterone is still the "King of the Road." Testosterone enanthate is the European counterpart to Testosterone cypionate which is predominantly available in the U.S. Testosterone enanthate, as most trade
names already suggest, is a long-acting depot steroid. Depending on the metabolism and the body's initial hormone level it has a duration of effect of two to three weeks so that theoretically very long intervals between injections are possible. Although Testosterone enanthate is effective for several weeks, it is injected at least once a week in bodybuilding, power lifting, and weightlifting. This, by all means, makes sense since Testosterone enanthate has a plasma half-life time in the blood of only one week.

3. Since most athletes who want to use STH can only obtain it if prescribed by a physician, the only

supply source remains the black market. And this is certainly another reason why some athletes might not have been very happy with the effect of the purchased compound. How could he, if cheap HCG was passed off as expensive STH? Since both compounds are available as dry substances, all that would be needed is a new label of Serono's Saizen or Lilly's Humatrope on the HCG ampule. It is no longer fun when somebody is paying $200 for 5000 I.U. of HCG, only worth $ 30, and thinking that he just purchased 4 I.U. of HGH. And if you think this happens only to novices and to the ignorant, ask Ben Johnson. "Big Ben,"

who during three tests within five days showed an above-limit testosterone level, was not a victim of his own stupidity but more likely the victim of fraud. According to statistics by the German Drug Administration, 42% of the HGH vials confiscated on the North American black market are fakes. In addition to a display of labels in the Dutch or Russian language the fakes are distinguished from the original product, in sofar as the dry substance is not present as lyophilic but present as loose powder. The fakes confiscated so far use the name "Humatrope 16" under the name of Lilly Company (with Dutch denomination)
or "Somatogen" (in Russian)." Nowhere can this much money be made except by faking STH. Who has ever held original growth hormones in his hand and known how they should look?

Because Phentermine may cause drowsiness, it is recommended that you take your dose early in the day. The best time is 30-60 minutes before breakfast, while your stomach is empty. Take the tablet in one piece, or, at most, it may be broken in two. Do not chew the tablet or crush it into a powder.

DHT Conversion: No

Vial and Cap

The claim that Nolvadex C&K reduces gains should not be taken

too seriously. The fact is that any number of bodybuilders have made excellent gains while using Nolvadex C&K. The belief that it reduces gains seems to stem from the fact that the scientific literature reports a slight reduction in IGF-1 (individuals using anabolic steroids were not studied though) from use of Nolvadex C&K. Thus, Dan Duchaine reported that it reduces IGF-1 and therefore reduces gains. However, if this effect exists at all, it must be very minor, due to the excellent gains that many have made, and from the fact that no one has noticed any such thing from Clomid, which has the same activity profile.

 - You must inform your doctor if you have ever had any mental illnesses like depression, suicidal behaviour or psychosis, or if you are using any medicine for these conditions.

    Molecular Weight: 300.3968

Trenabol 75 is a fast-acting injectable steroid with a great effect on protein metabolism. Trenbolone is one of the best effective anabolic compounds, promoting protein synthesis, as well as creating a positive nitrogen balance. It is an appetite stimulant and improves the conversion of proteins. In laboratory tests, it has been demonstrated that trenbolone

increases protein and decreases fat deposition. It has proven to be an excellent product for promoting size and strength in the presence of adequate protein and calories, promotes body tissue building processes, and can reverse catabolism.

Additional information

Withdrawal of treatment leads to gradual reversal of effect within 12 months.

The third reason for the popularity of Anavar is that oxandrolone does not influence the body's own testosterone production. This special feature of Anavar can be explained by the fact that the oxandrolone is not converted into estrogen.

Diazepam should

be administered cautiously to patients with severe hepatic disease because its elimination half-life can be prolonged, possibly resulting in toxicity. Diazepam is metabolized to an active metabolite, and patients with hepatic disease are more likely to experience adverse CNS reactions and should receive reduced initial dosages.

So how exactly does Testosterone build muscle? Well, Testosterone promotes nitrogen retention in the muscle (6), and the more nitrogen the muscles holds the more protein the muscle stores, and the bigger the muscle gets. Testosterone can also increase the levels of another anabolic

hormone, IGF-1, in muscle tissue (7). IGF-1 is, alone, highly anabolic and can promote muscle growth. It is responsible for much of the anabolic activity of Growth Hormone (GH). IGF-1 is also one of the few hormones positively correlated with both muscle cell hyperplasia and hyperphasia (this means it both creates more muscle fibers as well as bigger fibers). All of this leads me to speculate that for pure mass, IGF-1, GH, and Testosterone would be a very effective combination. Testosterone also has the amazing ability to increase the activity of satellite cells(8). These cells play a very active role in repairing damaged
muscle. Testosterone also binds to the androgen receptor (A.R.) to promote all of the A.R dependant mechanisms for muscle gain and fat loss (9), but clearly, as we´ve seen, this isn´t the only mechanism by which it promotes growth.

There are also suggestions of using clenbuterol in a two week on, two week off pattern, which makes sense when taking the characteristics, especially the long 35 hour half-time, of the compound in consideration. Tapering is not needed but can be suitable for some in order to avoid a possible "crash" period.

What role does HGH play in the body?

Blurring

or other visual symptoms such as spots or flashes may occasionally occur during therapy with Clomid. These visual symptoms increase in incidence with increasing total dose or therapy duration and generally disappear within a few days or weeks after Clomid is discontinued. These visual symptoms may render such activites as driving a car or operating machinery more hazardous than usual, particularly under conditions of variable lighting.

Anavar, oxandrolone, tablets. Each Anavar tablet contains 2.5 mg. oxandrolone. Anavar, brand name Bonavar, comes in packs of 50 tablets and is manufactured by Body Research Ltd.,

Thailand.

Available Doses: 50, 75, 100, 125, 200 or 250 mg/ml

The most common side effects when using tadalafil are headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. These side effects usually go away after a few hours. Back pain and muscle aches can occur 12 to 24 hours after taking the drug, and the symptom usually disappears after 48 hours.

Originally known as Winstrol, this oral or injectable steroid with a pronounced anabolic effect.

• Human Growth Hormone (HGH) is the most abundant hormone produced by the pituitary gland (pituitary is one

of the endocrine glands). The pituitary gland is located in the center of the brain.

Ingredient: Clonazepam

To some extent, nandrolone aromatizes to estrogen, and it does not appear that this can be entirely blocked by use of aromatase inhibitors ¨C indeed, aromatase may not be involved at all in this process (there is no evidence in humans that such occurs) with the enzyme CYP 2C11 being in my opinion the more likely candidate for this activity. In any case, Cytadren, an aromatase inhibitor, has not been found effective in avoiding aromatization of nandrolone.

Arimidex is quite expensive,

costing approximately $9 per milligram. With moderate doses of testosterone 0.5 mg/day is usually sufficient and in some cases may be too much.

If you are interested in taking clenbuterol for anything other than fat loss then you might as well stay away from this compound. There is a lot of talk as to how clenbuterol compares to ephedrine as well. Most "experts" feel that clen gives a better bang for the buck than the ECA stack. It should be noted that clenbuterol’s results and effects are much shorter lived. They work through very similar mechanisms. Both products stimulate the beta-receptors but

clenbuterol seems to be a more refined version, called a second generation beta-agonist drug, than ephedrine. Clenbuterol targets the proper receptors, being the beta-2 and 3 receptors than ephedrine more specifically which should in theory make clenbuterol more effective of a fat burner. Again, most of the so called "experts" say that clenbuterol is more effective than ephedrine. I, personally, get worse results with clen vs. the good old ECA stack. Clenbuterol also didn't blunt my hunger either and I ate more while taking it as well. I also seem to get much better effects out of cytomel as a fat burner as well.
Even better than the ECA stack or clenbuterol. But, again, that is my personal opinion.

If you take too much

Also, this drug is a poor choice for athletes who rely on cardiovascular fitness to play a sport. Tren, anecdotally at least, reduces many athletes ability to sustain high levels of endurance. Unfortunately, this makes Tren a poor choice for many.

Clenbuterol has a mild steroid like affect and can be used by athletes that do not use anabolic steroids, to increase lean body mass. A diet high in protein high in carbs and low in fat may work well for the average athlete.

ALTERNATIVE

STEROID NAMES: Winstrol, Stanabol, Stanabol injectable, Stanobol, Stanozolol.

Or if you observe that they have become: confused, disorientated, sweaty, drowsy.

So why else may you keep such a high proportion of what you gained on ´var? Well, I think it may be due to it´s relatively light impact on the HPTA, which brings me to my final point; Bonavar will not totally shut down your HPTA, especially at lower doses (unlike testosterone, which will eventually do this even at a 100mg dose, or deca which will do it with a single 100mg dose). This could be due, at least partly, to the fact that

Bonavar doesn´t aromatize (convert to estrogen).

The side effects of Durabolin are few. Water retention, high blood pressure, an el-evated estrogen level, and virilization symptoms occur less often with Durabolin than with Deca-Durabolin. Female athletes therefore take Durabolin in weekly intervals since, due to its short duration of effect, no undesirable concentration of androgen takes place. They achieve good results with 50 mg Durabolin/week, 50 mg Testosterone Propionate every 8 -10 days, and 8-10 mg Winstrol/day, or 10 mg Oxandrolone/day. Three to four day intervals between the relative injections

are to be observed. Durabolin is one of the safest non-toxic steroids offering satisfactory results. Durabolin has no negative effect on the liver function so it can even be taken in cases of liver disease. Side effects occur only in rare cases and in persons who are extremely sensitive. Virilization symptoms in women such as huskiness, deep voice, hirsutism, acne, and increased libido are possible but occur only rarely if reasonable dosages are taken at reasonable intervals. Men usually experience no symptoms with Durabolin. Since the release of gonadotropins in the hypophysis is inhibited, there is a chance that the
body's own testosterone production in a male athlete will be lower when the compound is taken over a prolonged time and in excessive doses.

Anavar should be taken two to three times daily after meals thus assuring an optimal absorption of the oxandrolone. Common dosage is 8-12 tablets in men and 5-6 tablets in women. The rule of thumb to take 0.125 mg./pound of body weight daily has proven successful in clinical tests.

Average Dose: Men 75 mg every day or two days

Each 10ml multidose vial contains 150mg per ml of dromastolone enanthate and 50mg of dromastolone propionate. Flip-off tops are gray-coloured

and have Mastabol Depot stamped on them.

 - Your must have discussed the risk of birth defects with your dermatologist.

Daniel Duchain wrote in "The Underground steroid handbook" : "If you can't grow on deca and d-bol you're not gonna grow anything, no matter how fancy it is".

Young bodybuilders should keep in mind that Testosterone heptylate could lead to an early stunting of growth since it prematurely closes the epiphysial growth plates. As for the availability on the black market it can be noted that Testosterone Heptylate Theramex is not as widespread as cypionate and enanthate.

The French, however, can purchase Testosterone Heptylate Theramex at a ridiculously low price in pharmacies.

Viagra is used as needed, so you are not likely to miss a dose.

It has been shown that greatest benefit can be had if an athlete consumes these high G.I. carbohydrate foods as soon as possible after an event, preferably within an hour or less. It is further recommended that a high carbohydrate intake be maintained during the next 24 hours. Miller suggests eating at least one gram of carbohydrate per kilogram body weight each 2 hours after prolonged heavy exercise and at least 10 grams

of high G.I. carbohydrate per kilogram body weight over the 24 hour period following this exercise.

Usage: Average dose is 50-100 mg a day.

Some individuals with the surname of "Cialis" objected to Lilly's naming of the drug, but the company insists that the drug's trade name has nothing to do with the surname.

Just as with the water-based injectable Winstrol, suspension too is believed to be able to give local growth if injected in a particular area, which has no doubt increased its popularity. Its slightly friendlier to inject than Winstrol or Propionate, because it has a very small crystalline

form that passes through a 27 gauge needle easily. But the injections will still not be the most pleasant ones ever felt. Especially when given daily. I myself do not attach a whole lot of belief to the theory of site injection and local growth, but some big names in this industry such as Bill Llewellyn seem to lend it some form of credibility. So I will not elaborate on this debacle anymore than I have. For those willing to give it a shot, I'm sure it can't hurt (well it will hurt, but it won't hurt your gains no matter where you inject it).

Somatotropin HGH / 10vials / original box Description Somatotropin

hgh by EuroHormones

At one time oxandrolone was also looked at as a possible drug for those suffering from disorders of high cholesterol or triglycerides. Early studies showed it to be capable of lowering total cholesterol and triglyceride values in certain types of hyperlipidemic patients, which initially this was thought to signify potential for this drug as a hypo-lipid (lipid lowering) agent. With further investigation we find however that while use of this drug can be linked to a lowering of total cholesterol values, it is such that a redistribution in the ratio of good (HDL) to bad (LDL) cholesterol occurs,

usually moving values in an unfavorable direction. This would of course negate any positive effect that the drug might have on triglycerides or total cholesterol, and in fact make it a danger in terms of cardiac risk when taken for prolonged periods of time. Today we understand that as a group anabolic/androgenic steroids produce very unfavorable changes in lipid profiles, and are really not useful in disorders of lipid metabolism. As an oral c17 alpha alkylated steroid, oxandrolone is probably even more risky to use than an injectable esterified injectable such as a testosterone or nandrolone in this regard.

Primobolan Acetate is a naturally occurring hormonal analog that is orally bioavailable and active in it’s original form. This new class of hormone analog does not require conversion into another form of synthetic testosterone like most pro-hormones. Primobolan Acetate orals stimulate the natural production of total and active testosterone. It does this by regulating estrogen biosynthesis which produces a signal in the body to promote luteinizing hormone (LH) and decrease (SHBG) in order to increase natural production of testosterone while simultaneously stimulating free or active testosterone.

Highlights:

Inhibits estrogen formation.
Orally active in its original form, No conversion necessary
Stimulates natural production of total and free testosterone
Long term use recommended - Does not need to be cycled
Does not breakdown into banned substances or metabolites
Promotes fat free mass, strength and endurance
Can be taken alone or may be stacked with other steroids & pro-steroids

The chemical term 4-Androstenoldione Acetate refers to the isomer: 4-Androsten-4-ol-3beta,17beta-dione Acetate. 4-Androstenoldione Acetate is the acetate ester derivative of 4-Hydroxy-4-Androstenedione, which is an analog or derivative of the naturally occurring precursor hormone 4-Androstenedione. This compound concerns the isomer form of 4Androsten-4-ol-3beta,17beta-dione Acetate.

4-Androstenoldione Acetate is a steroidal aromatase inhibitor that inhibits estrogen biosynthesis, increases natural production of total and free testosterone, and may inhibit DHT formation. It does this by inhibiting the Cytochrone P-450 enzyme, which converts testosterone to estrogen. Once estrogen levels fall a signal is sent to the hypothalamic pituitary axis to produce (LH) luteinizing hormone and decrease (SHBG) steroid hormone binding globulin. LH then stimulates the testes to increase total testosterone production, in which a large portion is free or active testosterone due to the decrease in SHBG. This increased amount of testosterone is then metabolized with less estrogen and DHT conversion.

The compound is mainly eliminated by metabolism, renal excretion of metabolites accounting for 95% of dose. The excretory balance of 14C-compounds in urine and feces totals up to 98.9+/-0.8% of the i.v. dose after 168 h. The 14C-compounds in plasma and urine were separated by HPLC, and three major metabolites were submitted to structural analysis by MS, NMR and UV spectroscopy. One of the metabolites is the direct 4-O-glucuronide of formestane. The other two represent 3-O-sulfates of the exocons 3beta,4beta-dihydroxy-5alpha-androstane-17-one and 3alpha,4beta-dihydroxy-5alpha-androstane-17-one, their ratio being 7:3. These exocons are formed by stereoselective 3-keto reduction, accompanied by reduction of the 4,5-enol function. The exocons do not inhibit human placental aromatase activity in vitro.

The half-life orally was approximately 3 h, whereas the apparent half-life of injected drug was between 5 and 10 days after a more rapid clearance during the first 4 days after injection. The formulated material achieved a significantly higher mean peak concentration (88% greater than that obtained using the unformulated powder) and a higher mean AUC (not significant). The median time to peak was 1.5 h for both preparations and the elimination rate constants were similar (0.31 for micronized 4-OHA and 0.36 h-1 for formulated 4-OHA). Significant biological activity was demonstrated with the formulated material in its suppression of plasma oestradiol levels.

Another interesting note is the ability of 4-Androsten-4-ol-3, 17-dione acetate to directly stimulate testosterone whether in the presence of LH or not. Researchers examined the effects of placebo, luteinizing hormone (LH), 4-acetoxy-4-androstenedione, and luteinizing hormone (LH) plus 4-acetoxy-4-androstenedione on rat follicles in vitro. In regards to testosterone they found that within the first 8 hours 4-acetoxy-4-androstenedione had the ability to directly stimulate testosterone alone and greatly stimulate testosterone in combination with luteinizing hormone (LH). Interestingly enough within the next 16 hours they discovered 4-acetoxy-4-androstenedione alone was stimulating testosterone 3 times as much as luteinizing hormone (LH) while the combination also continued to stimulate testosterone.

Estrogen inhibition was significant with 4-Androsten-4-ol-3, 17-dione acetate alone producing the greatest inhibition at both 8 and 24 hour intervals.

Primobolan Acetate [4-Androsten-4-ol-3beta,17beta-dione Acetate for oral ingestion] is indicated for the long-term promotion of testosterone and regulation of estrogen in humans.

As a dietary supplement, take 1 to 2 tablets 3 times daily. Do not exceed recommended dose. The recommended daily dose in adults is 1-5 mg/kg body weight per day. The usual effective dose is 1-2 mg/kg/day but higher doses may be required, and the dose should be individualized. Response is not often immediate, and a minimum trial of three to six months should be given.

Not to be used with any other medications especially oral hypoglycemic agents ie. Glyburide. Not for use by individuals under the age of 18. Do not use if you are pregnant, contemplating pregnancy or lactating. Consult a physician prior to use if you have any medical condition.