It is easy

on the liver and promotes good size and strength gains while reducing body fat. Deca can be used by almost all athletes, with positive results and very few side effects, deca has gained a reputation as being somewhat of an alleviator of sore joints and tendons. Athletes report that sore shoulders, knees and/or elbows are somehow without pain on the Deca cycle.

Xenical may cause some side effects that are usually mild to moderate and decrease after the first week of the treatment. The most common side effects are fatty/oily stool, oily spotting, intestinal gas with discharge, bowel movement urgency, poor bowel control,

or headaches may occur. If these effects persist or worsen, notify your doctor promptly. Intestinal side effects (e.g., oily stool) may increase in intensity if you exceed your daily dietary fat allowance. If you notice other effects not listed above, contact your doctor.

XENICAL is a prescription weight-control medication useful for the long-term treatment of significant obesity.

Of course testosterone cypionate can be stacked with any number of compounds apart from these, but these make the best match. When stacking with testosterone, one needs to look at what the other compound can bring. Either it

has a characteristic that testosterone doesn't have, or its nominally safer. The testosterone will bring all the mass, so adding another steroid to enhance mass alone, is futile. More testosterone is the best remedy for that.

Detection Time: 5 months

Xenical is indicated for obesity management including weight loss and weight maintenance when used in conjunction with a reduced-calorie diet. Xenical is also indicated to reduce the risk for weight regain after prior weight loss.

Ingredient: Clonazepam

Suggested dosage Take per 50mg day- 2 to 3 tabs in the morning and 2 to 3 in the evening.

The cycle should last no more than 12 weeks whilst the injections can go on for a longer period up to 14 weeks. Stack with Nandrolone Decanoate (Deca) or Testosterone Compund (Sustanon). If taken alone then consume 500 tablets over a 12 week period.

Discussion

It is interesting to note that Anadrol 50 does exhibit some tendency to convert to dihydrotestosterone, although this does not occur via the 5-alpha reductase enzyme (responsible for altering testosterone to form DHT) as it is already a dihydrotestosterone based steroid. Aside from the added c-17 alpha alkylation, oxymetholone differs from DHT only

by the addition of a 2-hydroxymethylene group. This grouping can be removed metabolically however, reducing oxymetholone to the potent androgen l7alpha-methyl dihydrotestosterone (mesterolone; methyldihydrotestosterone). There is little doubt that this biotransformation contributes at least at some level to the androgenic nature of this steroid, especially when we note that in its initial state Anadrol 50 has a notably low binding affinity for the androgen receptor. So although we have the option of using the reductase inhibitor finasteride (Proscar) to reduce the androgenic nature of testosterone, it would be of no benefit
with Anadrol 50 as this enzyme is not involved.

Proviron reduces either levels of estrogen or the effect of estrogen. Thus, it is useful for avoiding gynecomastia, although it probably should not be relied upon as the sole drug for that. It is not hepatotoxic. It has the usual side effects of anabolic/androgenic steroids, with the added effect that it is particularly prone to cause erections.

Formula (ester): C2 H4 O2

Liver Toxic: Very

We also discussed that certain steroids may indeed stimulate and act at the height of the progesterone receptor including nandrolone and Norethandrolone.

These hormones are also altered by it inducing a decrease in libido and a sense of lethargy and such, and eventhough they aromatize in lesser rates than some other steroids, they show an equal capability to cause estrogenic side-effects, particularly when stacked with other aromatizable compounds. Now there is evidence that Winny does indeed bind to the progesterone receptor1 and its users do not indicate the normal characteristics of progesterone stimulation, which bodes well for these anti-progestagenic properties. There is also some clinical data that it does aid in symptoms that require progesterone suppression

2. Much in the way danazol was also successfully used. The one thing we shouldn't lose sight of however is in what rate it binds to the progesterone reception. There is no data on this. For all we know it couldn't bind strong enough to compete with nandrolone or norethandrolone. So its not wise to state that Winny is an anti-progestagin per se, but it does make Winny a good match for these products in stacks in any case.

Package: 10ml (2000mg/bottle)

Pregnyl by Organon.1,500 to 5,000 (International Units) per 1ml amps. This drug is not a steroid but it is widely used in athletics today.

HCG is a natural protein hormone secreted by the human placenta and purified form the urine of pregnant women. This hormone is not a natural male hormone but mimics the natural hormone LH (Luetinising Hormone) almost identically. This LH stimulates the production of testosterone by the testis in males. Thus HCG sends the same message and results in increased testosterone production by the testis due to HCG’s effect on the leydig cells of the testis. Normally this HCG is used to treat women with certain ovarian disorders and it is used to stimulate the testis of men who may be hypogonadal. Athletes use HCG to increase the

body’s own natural production of testosterone which is often depressed by long term steroid use. Also when steroids are used in high dosages they can cause false signals to the hypothalamus that results in a depressed signal to the testicles. Over a period of weeks of this depressed signal the testicles ability to respond to any signal from the pituitary becomes very weak, which results in testicular atrophy. To avoid this athletes will use HCG to keep an artificial signal going to the testis and preventing testicular atrophy.

Most athletes actually prefer to use both Proviron and Nolvadex, especially during strongly

estrogenic cycles. Proviron and Nolvadex attack estrogen at a different angle, side effects are often greatly minimized.

Chemical structure: 4-androstene-3-one,17beta-ol

Normally nerves or blood vessels in men with male erectile dysfunction do not work properly, which prevents them from achieving an erection. Viagra works to restore the blood flow to the penis making it easier to achieve and sustain longer erections.

• It improves healing capacity- (71%)

There is no research to site on exactly what dosage would be the most appropriate for a steroid user. Logic woul dictate that

the typically prescribed amount of Harifin / Propecia, a single 1mg tablet per day, would most likely be sufficient. In clinical trials the effect of just a single tablet is clearly dramatic.

Many have speculated as to what makes Anapolon so troublesome in terms of estrogenic side effects. Some have suggested that it has progestational activity, similar to nandrolone, and Anapolon is not actually estrogenic at all. Since the obvious Anapolon side effects of both estrogens and progestins are very similar, this explanation might be a plausible one. However we do find medical studies looking at this possibility.

Anapolon (Oxymetholone) is also a very potent androgen. This trait tends of Anapolon to produce many pronounced, unwanted androgenic side effects.

At 40 years old we produce an average 200 micrograms/day of HGH.

DNP (2,4-Dinitrophenol)

Apnea, hypotension, and cardiac arrest have been reported following parenteral administration of benzodiazepines to the elderly, severely ill patients, or patients with compromised respiratory function. Respiratory depression also has occurred in these patients during benzodiazepine therapy, occasionally resulting in death.

by Bill Roberts - Nolvadex C&K

is very comparable to Clomid, behaves in the same manner in all tissues, and is a mixed estrogen agonist/antagonist of the same type as Clomid. The two molecules are also very similar in structure.

This drug is a potent nonsteroidal anti-estrogen. It is indicated for use in estrogen dependent tumors, i.e. breast cancer. Steroid users take Nolvadex to prevent the effects of estrogen in the body. This estrogen is most often the result of aromatizing steroids. Nolvadex can aid in preventing edema, gynecomastia, and female pattern fat distribution, all of which might occur when a man's estrogen levels are too high.

Also, these effects can occur when androgen levels are too low, making estrogen the predominant hormone. This can occur when endogenous androgens have been suppressed by the prolonged use of exogenous steroids. Nolvadex works by competitively binding to target estrogen sites like those at the breast. This drug is not toxic nor have any side effects been seen in athletes who used the drug\' as an anti-estrogen. This drug is the most popular anti- estrogen amongst steroid users. Although it does not turn out to be 100% effective for everyone, it does seem to exhibit some level of effectiveness for the majority.

In

addition, androgenic side effects are common with this substance, and may include bouts of oily skin, acne and body/facial hair growth. Aggression may also be increased with a potent steroid such as this, so it would be wise not to let your disposition change for the worse during a cycle. With Dianabol there is also the possibility of aggravating a male pattern baldness condition. Sensitive individuals may therefore wish to avoid this drug and opt for a milder anabolic such as Deca-Durabolin. While Dianabol does convert to a more potent steroid via interaction with the 5-alpha reductase anzyme (the same enzyme responsible

for converting testosterone to dihydrotestosterone), it has extremely little affinity to do so in the human body's. The androgenic metabolite 5alpha dihydromethandrostenolone is therefore produced only in trace amounts at best. Therefore the use of Proscar/Propecia would serve no real purpose.

EPO can be given intra-muscular or intravenously, of course with intravenously it will take effect much faster. With a half-life of 4 to 5 hours long, and when administered intra-muscular half-life will be 12 to 18 hours. So when used medically the dosage is 15-50IU/kg of body weight, given three times a week.

Conversion

of body fat to muscle mass

One reason for the extreme success users have had with testosterone suspension is no doubt the extreme doses used. Where one would take 50 mg of winstrol every day to every other day, suspension is injected daily at 100 mg in most cases. Factoring in that there is more testosterone per mg than in an esterified form, it's a safe conclusion that this is almost twice the dose of any other form of testosterone normally used. The results are nothing safe of amazing. Using the optimal peak doses of the steroid, weight is gained at an amazing rate and the steroid accumulates faster than with

esters, so gains are seen in a lot shorter time-frame as well. Stack that with another base steroid and an aromatizable oral such as Dianabol (methandrostenolone) and one should not be amazed at weight increases of up to 30 pounds in 8 weeks.

Enzyme production

If taken for 4 weeks, then run each dose for 4 days, 5 weeks then each dose for 5 days and so on. It is extremely important that the doses are tapered on and off and that a cycle never exceeds 6 weeks at the most.

Effective Dose: 16-30mg per day.

Trenbolone increases nitrogen retention in muscle tissue (5). This is of note because

nitrogen retention is a strong indicator of how anabolic a substance is. However, trenbolone´s incredible mass building effects do not end there. Trenbolone has the ability to bind with the receptors of the anti-anabolic (muscle destroying) glucocorticoid hormones (6). This may also has the effect of inhibiting the catabolic (muscle destroying) hormone cortisol (7).

Testosterone enanthate cycle

It tells us many things. Let's start with what we want, then see where that leads us. What do we want? Bigger muscles. More muscle cells that we will later grow with exercise and gear. A pump? Fatloss? Yeah,

right. You can get a pump with a good "pump" product for a quarter of the price of IGF-1. Fatloss? Clen/Alb and T3/T4 will give it to you again at a fraction of the price of IGF-1. More muscle cells, you can ONLY get with IGF-1 (and MGF too). Nothing else will give it to you and if you are using IGF-1 for anything else, you are misusing it. More muscle cells is CLEARLY the best use for IGF-1.

There have been an increasing number of American bodybuilders that are experimenting with this drug.

Nitrates are also found in illicit drugs such as amyl nitrate or nitrite (\"poppers\"). If you

are not sure if any of your medicines contain nitrates, or if you do not understand what nitrates are, ask your doctor or pharmacist. If you take VIAGRA with any nitrate medicine or illicit drug containing nitrates, your blood pressure could suddenly drop to an unsafe level. You could get dizzy, faint, or even have a heart attack or stroke.

Neo-Hombreol 50 mg/ml; Organon NL

Testosterone cypionate is an injectable oil which contains testosterone with the cypionate ester attached to the testosterone molecule. The ester denotes the release pattern of the test after it is injected into the body. This particular

ester gives the testosterone an active life of 15-16 days, although blood levels of this drug fall sharply five days post-administration, testosterone levels are still above baseline after a week (24). Stable blood levels can be achieved with once per week injections. Steriod.com members often administer the drug twice weekly or every three to five days days. On a funny side note, many steroid users believe that test cyp is more or less powerful than the other popular injectable testosterone enanthate. The truth is, they are almost identical in release patterns, so there is virtually no difference between the two. However,
as far back as the printing of the first Underground Steroid Handbook, there has been speculation that Cyp had more "kick" than Enth.

Bonavar Profile

It´s relatively high cost is its only major drawback when you buy Bonavar. Tablets can typically sell in Mexico or on the black market for up to a dollar (1USD) per 10mgs. Many black market dealers or Underground Labs, however offer capsules, liquid form (or in some cases, even their own brand of tabs) for substantially less money than the legit pharmaceutical versions, or even veterinary versions found overseas.

Athletes like to use

Nolvadex at the end of a steroid cycle since it increases the body's own testosterone production.

Pharmaceutical Name: Testosterone (as Cypionate)

Diazepam should be administered cautiously to patients with severe hepatic disease because its elimination half-life can be prolonged, possibly resulting in toxicity. Diazepam is metabolized to an active metabolite, and patients with hepatic disease are more likely to experience adverse CNS reactions and should receive reduced initial dosages.

• HGH is also a very complex hormone. It is made up of 191 amino acids. In fact, it is the largest protein

created by the pituitary gland.

The chance of finding real Danabolan on the black market is around 5%. That is the reason why we take a chance and claim that only very few of you who read this book will have ever held an original Danabolan in your hand, let alone injected one. Those who have not tried the originals simply cannot take part in this discussion. As to the effect, the difference between the real French Danabolan and the fakes circulating on the black market is gigantic.

The use of exogenous sources of Growth Hormone has been popular in the United States for almost 8 years now. Originally, athletes

used biologically active forms that were the actual extract of the pituitary glands of cadavers. Ascellacrin and Crescormon were the two most popular brand names on this original GH. While production was under way on the synthetic, recombinant DNA versions of this drug, it was discovered that the biologically active form was associated with the formation of a rare brain virus called Creutzveldt Jacob Disease. This was a fatal virus that afflicted a very small number of GH users, none of whom were athletes. In light of this discovery, the FDA removed all of these natural GH versions from the market in the United States.

Diazepam is classified as pregnancy category D because it can cause harm to the fetus when administered to pregnant women. Positive evidence of human fetal risk exists based on investigational, marketing, or human studies, but the potential benefit to the mother may outweigh the potential risks to the fetus. Diazepam is distributed into breast milk and can cause sedation, feeding difficulties, and weight loss in the nursing infant. The use of diazepam during breast-feeding is generally not recommended.

Chemical = Formula = Molecular Weight = Mg of Testosterone

Additional description for Provironum©

(mesterolone)

by Bill Roberts - This substance, used in some Australian veterinary products, is to be avoided by male bodybuilders. It is highly estrogenic, and has no redeeming properties. It is a poor anabolic and the mythical "receptor-cleaning" properties that have been claimed for it are pure fantasy.

This drug is unique (so far as I know) in that 5a -reductase, the enzyme which converts testosterone to the more-potent DHT, actually converts nandrolone to a less-potent compound. Therefore this AAS is somewhat deactivated in the skin, scalp, and prostate, and these tissues experience an effectively-lower

androgen level than the rest of the body. Therefore, for the same amount of activity as another drug at the androgen receptors (ARs) in muscle tissue, Deca gives less activity in the scalp, skin, and prostate. Thus, it is the best choice for those particularly concerned with these things.

Average Dose: Men 15-50 mg/day......Women 5-10 mg/day

The body will fight this, though, by cutting down on the amount of active thyroid in the body as well as through beta-receptor down regulation, which explains why clenbuterol is effective only over a limited time period.

Being a testosterone

product, all the standard androgenic side effects are also to be expected. Oily skin, acne, aggressiveness, facial/body hair growth and male pattern baldness are all possible. Older or more sensitive individuals might therefore choose to avoid testosterone products, and look toward milder anabolics like Deca-Durabolin or Equipoise which produce fewer side effects. Others may opt to add the drug Proscar/Propecia which will minimize the conversion of testosterone into DHT (dihydrotestosterone). With blood levels of this metabolite notably reduced, the impact of related side effects should also be reduced. With strong bulking
drugs however, the user will generally expect to incur strong side effects and will often just tolerate them. Most athletes really do not find the testosterones all that uncomfortable (especially in the face of the end result), as can be seen with the great popularity of such compounds.

You may know that ampoules are preferred by many because they are almost never counterfeit. You always get the real deal with us!

Tadalafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. The molecular structure

of tadalafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and better erections. Without sexual stimulation, and therefore lack of activation of the NO/cGMP system, tadalafil should not cause an erection. Other drugs that operate by the same mechanism include sildenafil (Viagra®) and vardenafil (Levitra®).

Take other medicines:

Parabolan is a strong, androgenic steroid which also has a high anabolic effect. Whether a novice, hard gainer, power lifter, or pro bodybuilder, everyone who uses Parabolan is enthusiastic about the results:

a fast gain in solid, high-quality muscle mass accompanied by a considerable strength increase in the basic exercises. in addition, the regular application over a number of weeks results in a well visible increased muscle hardness over the entire body without dieting at the same time. Frequently the following scenario takes place: bodybuilders who use steroids and for some time have been stagnate in their development suddenly make new progress with Parabolan. Another characteristic is that Parabolan, unlike most highly-androgenic steroids, does not aromatize. The substance trenbolone does not convert into estrogens so that
the athlete does not have to fight a higher estrogen level or feminization symptoms. Those who use Parabolan will also notice that there is no water retention in the tissue. To say it very clearly: Parbolan is the number one competition steroid. When a low fat content has been achieved by a low calorie diet, Parabolan gives a dramatic increase in muscle hardness. In combination with a protein rich diet it becomes espe-cially effective in this phase since Parabolan speeds up the metabolism and accelerates the burning of fat. The high androgenic effect prevents a possible overtraining syndrome, accelerates the regeneration,

and gives the muscles a full, vascular appearance but, at the same time, a ripped and shredded look.

Effective dosage: 2-4 IU, 2-4 times/week.

What kind of HGH supplements are available?

Testosterone propionate is a commonly manufactured, oil-based injectable testosterone compound. The added propionate ester will slow the rate in which the steroid is released from the injection site, but only for a few days. Testosterone propionate is therefore comparatively much faster acting than other testosterone esters such as cypionate or enanthate, and requires a much more frequent dosing schedule. While

cypionate and enanthate are injected on a weekly basis, propionate is generally administered (at least) every third day. Figure one illustrates a typical release pattern after injection. As you can see, levels peak and begin declining quickly with this ester of testosterone. To make Testosterone Propionate even more uncomfortable to use, the propionate ester can be very irritating to the site of injection. In fact, many sensitive individuals choose to stay away from Testosterone Propionate completely, their body reacting with a pronounced soreness and low-grade fever that may last for a few days. Even the mild soreness that
is experienced by most users can be quite uncomfortable, especially when taking multiple injections each week. The standard esters like enanthate and cypionate, which are clearly easier to use, are therefore much more popular among athletes.

What to tell your doctor

Trenbolone is derived from 19-nor Testosterone, but with three additional bonds- making it unable to aromatize (convert) to estrogen, as well as making it not subject to 5a-reduction (conversion to a Dihydro form). Speaking from a structural standpoint, Trenbolone is actually very similar to Deca-Durabolin (Nandrolone Decanoate), except for

a c-9 and c-11 double bond. These two double bonds are very important, however, and provide Trenbolone with several important differences. Firstly, the c9 bond serves to prevent aromatization (conversion) to estrogen, while the c11 double bond seems to increase Androgen Receptor binding quite profoundly (although this may also have something to do with the c9 bond as well). Thus, as compared with Deca, Trenbolone¡¯s lack of estrogenic activity and potent ability to bind to the androgen receptor allow it to be a much stronger anabolic/androgenic agent than Deca. So what we see in Trenbolone is a drug that¡¯s
roughly 4x as anabolic as Deca, and roughly 10x as androgenic (according to the Vida Reference scale). With Trenbolone, the majority of weight gained on this drug is lean and quality muscle. (1)

In bodybuilding and powerlifting Omnadren is exclusively used to build up strength and mass. The term "mass buildup" can be taken quite literally by the reader since the gain is not always the way expected by its user. In most athletes Omnadren leads to quite a rapid and pronounced increase in body weight, which usually goes hand in hand with a strong water retention. This results in watery and puffy muscles. Those

who take "Omna" can often be recognized by this extreme water retention. The often-used term in Europe, "Omna skull," does not come from nowhere but because a fast and well-visible water retention occurs also in the face which is noticeable on checks, on the front of the face, and under the eyes. Some mockingly also talk about a hydrocephalus... The pronounced androgenic component of Omnadren goes hand in hand with a high anabolic effect which manifests itself in a high strength gain characterized by a liquid accumulation in the joints, an increased pump effect, increased appetite, and a possible improved regeneration of
the athlete.

CLONAZEPAM is also known as RIVOTRIL.

Other Info: Highly anabolic/moderate androgenic effects

The side effects of Omnadren are similar to those of other testosterone compounds. Next to the high water retention other negative effects that are noticed are a sometimes strong acne and a distinctly increased aggressiveness in some users. An aggressive behavior can mostly be explained by the fact that athletes simply use too high a dosage of Omnadren and too low a dosage of the other (and more expensive) testosterones. The very severe acne, however, is only caused by Omnadren. Often no purulent

pustules but many small pimples appear so that the athlete looks as if he has an allergy. This is not intended to discourage anyone but it is a fact that many athletes after a brief time develop an acne on their lower arm, upper arm, shoulder, chest, back, and also in their face which, during an earlier intake of Sustanon or Testosterone enanthate, did not manifest itself.

Primobolan is sometimes opted for, and can be handy since it doesn't aromatize, which will make the total level of water retention and fat gain a lot less than with more test or with Deca for example. Unfortunately, its mild nature combined

with a lack of estrogen make Primobolan a very poor mass builder. Again, doses of 300-400 mg are used. I would actually suggest a higher dose, but with the current prices for Primo I don't think it would be very popular. My personal preference goes out to Equipoise. Androgenically its not that much stronger than Deca because it has next to no affinity for the 5-alpha-reductase enzyme and is only half as androgenic as testosterone. Its twice as strong as Deca, mg for mg, and has a lower occurrence of side-effects. It has some estrogen, but not a whole lot so it actually tends to lean a person out rather than bloat him up

as Deca will. It also increases appetite, which promotes gains, and improves aerobic performance, which may be wishful as testosterone normally has an opposite effect.

Individual results may vary. In clinical trials, CIALIS was shown to improve, up to 36 hours after dosing, the ability of men with ED to have a single successful intercourse attempt. CIALIS has not been studied for multiple sexual attempts per dose.

Molecular Basis for Efficacy

Day 3: 80 mcg

The major risk associated with insulin is a physical state known as hypoglycemia or "low blood sugar". This occurs when the level

of glucose in the blood falls below a certain level required for normal body function. If the blood glucose level is substantially reduced below this normal level and if this is not quickly corrected, there is a risk of disorientation, collapse, coma, permanent brain damage and even death. Exercise and reduced food intake decreases the body's need for insulin and increases the risk of hypoglycemia associated with non-medical use of insulin.

Anastrozole (Arimidex ®): Description

Chemical = Formula = Molecular Weight = Mg of Testosterone

Androlic / Anadrol is the most harmful oral steroid and

its intake can cause many considerable side effects. Most users can expect certain pathological changes in their liver values after approximately one week. Those who discontinue the use of oxymetholone will usually show normal values within two months. Oxymetholone is the only anabolic/androgenic steroid, which is linked with liver cancer.

Methandienone is a derivative of testosterone, exhibiting strong anabolic and moderate androgenic properties. This compound was first made available in 1960, and it quickly became the most favored and widely used anabolic steroid in all forms of athletics. This is likely due to

the fact that it is both easy to use and extremely effective. In the U.S. Dianabol production had meteoric history, exploding for quite some time, then quickly dropping out of sight. Many were nervous in the late 80's when the last of the U.S. generics were removed from pharmacy shelves, the medical community finding no legitimate use for the drug anymore. But the fact that Dianabol has been off the U.S. market for over 10 years now has not cut its popularity. It remains the most commonly used black market oral steroid in the U.S. As long as there are countries manufacturing this steroid, it will probably remain so.

Primoteston depot contains a derivative of the natural male sex hormone testosterone, testosterone enanthate as its active ingredient.

After intramuscular administration, testosterone enanthate becomes completely systemically available. The compound is gradually released from the depot with a half-life of about 4.5 days and is cleaved into testosterone and enanthic acid.

Maximum concentrations of testosterone of 20 ng/ml were measured 1.5 - 3 days after i.m. administration of 250 mg of testosterone enanthate to young men. Thereafter, testosterone levels in the plasma decreased with a half-life of about 4.5 days which corresponds to the release rate from depot.

Testosterone concentrations of=2 ng/ml were maintained for 20 days and concentrations=1 ng/ml for 26 days. With a dose of 250 mg testosterone enanthate, patients receive a total dose of 180 mg testosterone. Around the time where maximum serum levels are achieved, average daily doses after 1 and 2 weeks correspond to 12 and 4 mg testosterone, respectively. Within approximately 4 weeks after drug administration, testosterone is completely released from the depot.

Testosterone, which was generated by ester cleavage from testosterone enanthate, is metabolised and excreted the same way as endogenous testosterone. The enanthic acid is metabolised by ß-oxidation in the same way as other aliphatic carboxylic acids. The metabolic clearance of testosterone is calculated to be 16±7 ml/min/kg and refers to hepatic and extra-hepatic metabolism of testosterone. The metabolites of testosterone are eliminated with a half-life of 7.8 days. About 90 % are excreted renally and about 10 % with the bile.

Testosterone is highly bound to serum proteins, in particular to albumin and SHBG. The absolute bioavailability of testosterone from the ester was almost complete, indicating a rapid and efficient cleavage of the ester.

Injection of 250 mg testosterone enanthate every 3 - 4 weeks will not result in any clinically relevant accumulation of testosterone in serum.

Like all oily solutions, Primoteston depot must be injected intramuscularly. Experience shows that the short-lasting reactions (urge to cough, coughing fits, respiratory distress) which occur in rare cases during or immediately after the injection of oily solutions can be avoided by injecting the solution extremely slowly.

Disorders of potency based on an androgen deficiency are eliminated by administration of Primoteston depot. Mental changes, stress and conflict situations and physical ailments are frequently predominant in potency disorders. Supportive therapy with androgens can be beneficial during the elimination and treatment of causative factors and disorders.

For the therapy of diminishing androgen production - frequently with onset in middle age - and its possible concomitant symptoms, e.g. reduced performance, rapid fatigability, diminishing memory and ability to concentrate, disorders of libido and potency, depressive moods, irritability, sleep disturbances, general vegetative complaints.

The solvent of Primoteston depot has been used for many years in numerous formulations for human use. In this time no local irritant effects have been observed which could object to its further use. Many years of clinical experience have shown only sporadic cases in which allergenic reactions have been suspected. No clear sensitising effect has been proven.

On the whole, the available toxicological findings do not present any objections to the prescriptive use of Primoteston depot in humans for the given indications and at the dosages prescribed.

Adverse Effects
High-dosed or long -term administration of testosterone occasionally increases the tendency to water retention and oedema. Caution should therefore be exercised in patients predisposed to oedema.

In very rare cases jaundice and liver function test abnormalities were reported. Rare cases of polycythemia were reported. Gynaecomastia may occur in rare cases. Acne may occur.

Depending on the individual sensitivity to androgenic impulses, women may develop signs of virilisation, e.g. acne, hirsutism, voice changes (particular care is necessary in women whose occupations involve singing or speaking).

Interactions
Phenobarbital increases the break down of steroid hormones in the liver (possible impairment of efficacy).

The clotting status should be monitored particularly closely when Primoteston depot is administered together with coumarin derivatives.